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Volume 1, No 1 - Winter 2001

Volume 1, No 1 - Winter 2001

Table of Contents

Dyspepsia, Irritable Bowel Syndrome, and Constipation: Review and What's New Gastrointestinal Disorders
Functional gastrointestinal disorders are collections of symptoms attributable to the gastrointestinal tract in the absence of mucosal, structural, or biochemical disease. The two most common disorders, irritable bowel syndrome and functional dyspepsia, have common etiopathogenetic features, notably psychosocial disturbances, d y s m o t i l i t y, heightened sensitivity, and, possibly, an association with a postinfective state. The third condition is constipation, in which transit disorders and abnormal evacuation represent disturbances of function that are amenable to therapy. This review is an update of the control mechanisms, p a t h o p h y s i o l o g y, investigation, and potential pharmacotherapies of these disorders. Serotonergic and adrenergic agents and neurotrophic factors are among the novel approaches that may have a significant impact on these disorders [Rev Gastroenterol Disord. 2001;1(1):2-17]
Colorectal Cancer Screening and Surveillance: The Present and the Future Emerging Treatment
Colorectal cancer screening is now proven to be effective and is widely endorsed by guidelines committees. Several forms of screening have merit, but the screening tests used in individual patients are often dictated by insurers. The use of screening colonoscopy is expected to increase. Gastroenterologists will play the central role in ensuring the safe and cost-effective application of colonoscopy to screening and surveillance. [Rev Gastroenterol Disord. 2001;1(1):18–31]
Esomeprazole Magnesium (Nexium) New Drug Review
Esomeprazole, the S-isomer of omeprazole, is a new proton pump inhibitor. Esomeprazole provides better control of intragastric pH than omeprazole. It is more effective in treating erosive esophagitis in patients with GERD than omeprazole. Esomeprazole can maintain the healing of erosive esophagitis when used daily or on demand. It is also effective for the eradication of Helicobacter pylori infections. The incidence and type of adverse events associated with esomeprazole therapy are infrequent and likely to be similar to omeprazole. [Rev Gastroenterol Disord. 2001;1(1):32—41]
Advances in Liver Disease 51st Annual Meeting of the American Association for the Study of Liver Diseases