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Volume 9, No 1 - Winter 2009

Volume 9, No 1 - Winter 2009

Table of Contents

Third Eye Retroscope: Rationale, Efficacy, Challenges Technology Update
The most effective colonoscopy misses polyps, and both barium enema and computed tomography colonography studies have identified hidden areas on the proximal sides of folds, flexures, and valves where colonoscopy can miss even substantially sized lesions. This article reviews the rationale, efficacy, and clinical challenges associated with one of the most promising devices for improvement of mucosal exposure during colonoscopy, the Third Eye® Retroscope® (Avantis Medical, Sunnyvale, CA).[Rev Gastroenterol Dis. 2009;9(1):1-6]
Bifidobacterium infantis 35624: A Novel Probiotic for the Treatment of Irritable Bowel Syndrome Treatment Update
Irritable bowel syndrome (IBS) is a common disorder with widespread prevalence. Due to its heterogeneous pathogenesis, efficacious treatments are lacking. The few medications that are effective for treating global IBS symptoms have either been withdrawn or restricted due to detrimental side effects; thus, safe and effective alternatives are urgently needed. Increasing data have revealed that inflammatory changes may play a role in the development of IBS, and probiotics, commensal organisms with inherent health benefits, may alter that milieu. Although their exact mechanisms of action remain elusive, it is clear that the beneficial properties inherent to each probiotic species are strain specific. Bifidobacterium infantis 35624 ( B infantis 35624; Bifantis, The Procter & Gamble Company, Cincinnati, OH), is a probiotic with unique abilities to reduce intestinal inflammation. Two randomized, controlled trials have validated its efficacy for treating both individual and global IBS symptoms without evidence to suggest an increase in adverse events. B. infantis 35624 appears safe and effective for the treatment of IBS.[Rev Gastroenterol Dis. 2009;9(1):7-15]
Definitive Therapy for Internal Hemorrhoids—New Opportunities and Options Treatment Update
Hemorrhoids are common in Western societies. Appropriate assessment and treatment of symptomatic hemorrhoids can substantially reduce morbidity and improve patient well-being. In this article, the clinical presentation, differential diagnoses, and current treatment options, including the CRH-O’Regan banding device, an emerging technology for the anoscopic treatment of symptomatic internal hemorrhoids, are reviewed.[Rev Gastroenterol Disord. 2009;9(1):16-26]
Highlights From the 59th Annual Meeting of the American Association for the Study of Liver Diseases, October 31-November 4, 2008, San Francisco, CA Emerging Therapy for Chronic Hepatitis C
Highlights From the 59th Annual Meeting of the American Association for the Study of Liver Diseases, October 31-November 4, 2008, San Francisco, CA[Rev Gastroenterol Dis. 2009;9(1):27-34]
Infectious Disease News and Views From the Literature