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Volume 3, No 2 - Spring 2010

Volume 3, No 2 - Spring 2010

Table of Contents

Management Strategies for Painful Bladder Syndrome Management Update
Painful bladder syndrome/interstitial cystitis (PBS/IC) is a condition of chronic pelvic pain associated with irritative voiding symptoms. Management of PBS/IC has been a challenge for generations of physicians, owing to a lack of consensus on its definition, an incompletely understood pathophysiology, and numerous available therapies without high-quality evidence to guide their usage. This article reviews the most current conception of PBS/IC and data on effective treatments to recommend a management strategy. [Rev Obstet Gynecol. 2010;3(2):42-48 doi: 10.3909/riog0103]
The Role of In Vitro Directed Chemotherapy in Epithelial Ovarian Cancer Treatment Update
Epithelial ovarian cancer (EOC) continues to be the most lethal gynecologic malignancy. Efforts to personalize chemotherapy treatments by utilizing in vitro tumor assays to predict chemotherapeutic response have been tested in both the primary and recurrent treatment setting. To date, several retrospective studies have suggested improved response rates to predicted chemotherapeutic agents. However, a prospective, controlled trial merely found equivalence between in vitro prediction and empirical treatment selection. This review summarizes the current data regarding in vitro directed chemotherapy in EOC. [Rev Obstet Gynecol. 2010;3(2):49-54 doi: 10.3909/riog0112]
Hormonal Contraceptive Options for Women With Headache: A Review of the Evidence Management Update
Migraine affects as many as 37% of reproductive-age women in the United States. Hormonal contraception is the most frequently used form of birth control during the reproductive years, and given the significant proportion of reproductive-age women affected by migraine, there are several clinical considerations that arise when considering hormonal contraceptives in this population. In this review, key differences among headache, migraine, and migraine with aura, as well as strict diagnostic criteria, are described. The recommendations of the World Health Organization and the American College of Obstetricians and Gynecologists regarding hormonal contraception initiation and continuation in women with these diagnoses are emphasized. Finally, information about the effect of hormonal fluctuations on headache is provided with recommendations regarding contraception counseling in patients who experience headache while taking hormonal contraception. [Rev Obstet Gynecol. 2010;3(2):55-65 doi: 10/3909/riog0113]
HIV and Pregnancy in Resource-Poor Settings Women's Health in the Developing World
There are 33.4 million people living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome. Globally, HIV/AIDS is the leading cause of death among women of reproductive age. In the United States and other developed countries, aggressive efforts to treat HIV-positive pregnant women with highly active antiretroviral therapy have decreased the maternal-to-child transmission (MTCT) from over 20% to less than 2%. However, in resource-poor settings, access to antiretroviral therapy (ART) is not readily available, and perinatal transmission rates remain as high as 45%. Women are at greater risk of heterosexual transmission of HIV, which is compounded by lack of condom use, imbalance of social power, and the high fertility rate. Prevention programs are needed to empower and educate women and engender community awareness for condom use. Prenatal screening and treatment, intrapartum ART, and postpartum prophylaxis must be made available to all women and children to prevent MTCT. [Rev Obstet Gynecol. 2010;3(2):66-71 doi: 10.3909/riog0118]
Preeclampsia Reviewing the Literature
Breast Cancer Reviewing the Literature
Miscarriage Reviewing the Literature
Miscellaneous Reviewing the Literature
Labor Reviewing the Literature